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Publications

GOOGLE SCHOLAR

Selected Publications:

  1.  [1][2]Pek RH, Yuan X, Rietzschel N, Zhang J, Jackson LK, Nishibori E, Ribeiro A, Simmons WR, Jagadeesh J, Sugimoto H, Alam MZ, Garrett LJ, Haldar M, Ralle M, Phillips J, Bodine D, Hamza I. Hemozoin produced by mammals confers heme tolerance. eLife, 2019; 8:e49503 (eLife Digest). 
  2. [3][4]Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, and Hamza I.  Inter-organ signaling by HRG-7 promotes systemic heme homeostasis Nature Cell Biol. 2017;19:799-807.
  3. Yuan X, Rietzschel N, Kwon H, Nuno Da Silva ABW, Hanna DA, Phillips J, Raven E, Reddi AR and Hamza I. Regulation of intracellular heme trafficking revealed by subcellular reporters.  Proc Natl Acad Sci, 2016; 113:E5144-5152. 
  4. Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I.  Control of metazoan heme homeostasis by a conserved multidrug resistance protein.  Cell Metab. 2014;19:1008-1019.
  5. [5] White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD and Hamza I.  HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.  Cell Metab. 2013; 17: 261-270.
  6. [6] [7] [8] Chen C, Samuel TK, Sinclair J, Dailey H and Hamza I. An intercellular heme trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell. 2011; 145:720-731.
  7. [9] [10] [11] Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I. Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008; 453: 1127-1131 (Epub Apr 16, 2008). 

Selected Reviews:

  1. Chambers IG, Willoughby MM, Hamza I, Reddi AR. One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers. Biochim Biophys Acta Mol Cell Res 2021, 1868(1):118881. 
  2. Soares MP and Hamza I.  Macrophages and iron metabolism.  Immunity 2016 Mar 15;44(3):492-504.
  3. Korolnek T and Hamza I.  Macrophages and iron trafficking at the birth and death of red cells.  Blood. 2015 May 7;125(19):2893-2897. Epub 2015 Mar 16.
  4. Hamza I and Dailey H. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in eukaryotes. Biochim Biophys Acta- Molecular Cell Research. 2012;1823:1617-1632.
  5. Severance S and Hamza I.  Trafficking of Heme and Porphyrins in Metazoa. Chem. Rev. 2009; 109:4596-4616.

[1]  Highlighted in eLife Digest       
[2]  Highlighted in Press releases: https://www.sciencedaily.com/releases/2019/10/191001110822.htm       
[3]  Highlighted in Press releases: https://www.sciencedaily.com/releases/2017/06/170605121303.htm       
[4]  News & Views: Inter-organ regulation of haem homeostasis. Pitt JN and Kaeberlein M.  Nat Cell Biol. 2017 Jun 29;19:756-758.       
[5]  Highlighted in Press releases: http://www.sciencedaily.com/releases/2013/02/130205131752.htm       
[6]  Highlighted in Press releases: http://www.sciencedaily.com/releases/2011/05/110526122909.htm  and       
http://www.futurity.org/health-medicine/from-worms-clues-to-how-iron-moves/       
[7]  Recommended by the Faculty of 1000 Biology, http://f1000.com/11215956; F=6       
[8]  Research Highlight: Intercellular trafficking: Heme to go. Nat Chem Biol 2011; 7:496–497       
[9]  Modern Marvels: Iron, History Channel, Aug 14, 2008       
[10]  Highlighted by United Press International, Worms help in iron deficiency research, April 16, 2008       
http://www.sciencedaily.com/releases/2008/04/080416140912.htm       
[11]  Recommended by the Faculty of 1000 Biology, http://f1000.com/1105036; F=9OK

(Want an updated list? Use NCBI MY BIBLIOGRAPHY)

  1. Belot A, Puy H, Hamza I, Bonkovsky HL. Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy. Liver Int. 2024 Jun 18. doi: 10.1111/liv.15965. 
  2. Hopp MT, Vaidya SM, Grimmig KM, Strudthoff LJ, Clauser JC, Yuan X, Singh S, Müller J, Oldenburg J, Hamza I, Imhof D. Quantitative analysis of heme and hemoglobin for the detection of intravascular hemolysis. Anal Chim Acta. 2024 Jul 11;1312:342766. doi: 10.1016/j.aca.2024.342766. Epub 2024 May 21. 
  3. Chen C and Hamza I. Notes from the Underground: Heme Homeostasis in C. elegans. Biomolecules. 2023 Jul 19;13(7):1149. doi: 10.3390/biom13071149. 
  4. Sun F, Zhao Z, Willoughby MM, Shen S, Zhou Y, Shao Y, Kang J, Chen Y, Chen M, Yuan X, Hamza I, Reddi AR, Chen C. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Nature 2022 610(7933):768-774. 
  5. Dutt S, Hamza I, Bartnikas TB. Molecular mechanisms of iron and heme metabolism.  Annu Rev Nutr. 2022 May 4. doi: 10.1146/annurev-nutr-062320-112625. 
  6. Chambers I, Kumar P, Lichtenberg J, Wang P, Yu J, Phillips J, Kane MA, Bodine D, Hamza I. MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function. Proc Natl Acad Sci U S A 2022, 119(6). 
  7. Hanna DA, Moore CM, Liu L, Yuan X, Dominic IM, Fleischhacker AS, Hamza I, Ragsdale SW, Reddi AR. Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. J Biol Chem 2022, 298(2):101549. 
  8. Simmons WR, Wain L, Toker J, Jagadeesh J, Garrett LJ, Pek RH, Hamza I, Bodine DM. Normal Iron Homeostasis Requires the Transporter SLC48A1 for Efficient Heme-Iron Recycling in Mammals. Front Genome Ed 2020, 2:8.
  9. Bergmann A, Floyd K, Key M, Dameron C, Rees KC, Thornton LB, Whitehead DC, Hamza I, Dou Z. Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection. PLoS Pathog. 2020 May 14;16(5):e1008499. doi: 0.1371/journal.ppat.1008499.
  10. Laranjeira-Silva MF, Hamza I and Pérez-Victoria JM. Iron and heme metabolism at the Leishmania-host interface.  Trends Parasitol. 2020 Mar;36(3):279-289.XXX
  11. Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Structural insights into heme binding to IL-36α proinflammatory cytokine. Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0.
  12. Zhang J and Hamza I. Zebrafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis.  Mol Genet Metab. 2018 Dec 24. pii: S1096-7192(18)30626-7.XXX
  13. Zhang J, Chambers I, Yun S, Phillips J, Krause M, Hamza I.  Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney.  PLoS Genet. 2018 Sep 24;14(9):e1007665. doi: 10.1371/journal.pgen.1007665. eCollection 2018 Sep.
  14. Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H.  Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.  Commun Biol. 2018 Aug 17;1:120. doi: 10.1038/s42003-018-0121-8. eCollection 2018.
  15. Laranjeira-Silva MF, Wang W , Samuel TK , Maeda FY , Michailowsky V, Hamza I, Liu Z, and Andrews NW. A MFS-like plasma membrane transporter promotes Leishmania virulence by protecting the parasites from iron toxicity. PLoS Pathog. 2018 Jun 15;14(6):e1007140. doi: 10.1371/journal.ppat.1007140. [Epub ahead of print]
  16. Yuan X, Hamza I. Cys links heme: Stereo-orientation of heme transfer in cytochrome c biogenesis. J Mol Biol. 2018 Mar 3. 
  17. Chen AJ, Yuan X, Li J, Dong P, Hamza I, Cheng JX. Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy. Anal Chem. 2018 Mar 6;90(5):3395-3401
  18. Gouveia Z, Carlos AR, Yuan X, Aires-da-Silva F, Stocker R, Maghzal GJ, Leal SS, Gomes CM, Todorovic S, Iranzo O, Ramos S, Santos AC, Hamza I, Gonçalves J, Soares MP.  Characterization of plasma labile heme in hemolytic conditions.  FEBS J. 2017 Aug 7. doi: 10.1111/febs.14192.
  19. Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption.  PLoS One. 2017;12:e0181117.
  20. Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, and Hamza I.  Inter-organ signaling by HRG-7 promotes systemic heme homeostasis Nature Cell Biol. 2017;19:799-807. Download PDF
  21. Yuan X, Rietzschel N, Kwon H, Nuno Da Silva ABW, Hanna DA, Phillips J, Raven E, Reddi AR and Hamza I. Regulation of intracellular heme trafficking revealed by subcellular reporters.  Proc Natl Acad Sci, 2016. Download PDF
  22. Hanna DA, Harvey RM, Martinez-Guzman, Yuan X, Chandrasekharan B, Raju G, Outten FW, Hamza I, and Reddi AR.  Heme Dynamics and Speciation Revealed by Genetically Encoded Fluorescent Heme Sensors.  Proc Natl Acad Sci, 2016;113:7539-7544. Download PDF
  23. Luck AN, Yuan X, Voronin D, Slatko BE, Hamza I, and Foster JM.  Heme Acquisition in the Parasitic Filarial Nematode, Brugia malayi. FASEB J. 2016 Jun 30. pii: fj.201600603R. [Epub ahead of print] Download PDF
  24. Reddi AR and Hamza I.  Heme mobilization in animals: A metallolipid’s journey.  Acc Chem Res. 2016;49:1104-1110. Download PDF
  25. Soares MP and Hamza I.  Macrophages and iron metabolism.  Immunity 2016 Mar 15;44(3):492-504. Download PDF
  26. Marciano O, Moskovitz Y, Hamza I, Ruthstein S.  Histidine residues are important for preserving the structure and heme coordination site of the C. elegans HRG-3 heme trafficking protein. J Biol Inorg Chem. 2015 Dec;20(8):1253-61.Download PDF
  27. Renberg R, Yuan X, Samuel TK, Miguel DC, Hamza I, Andrews NW and Flannery AR. The heme transport capacity of LHR1 determines the extent of virulence in Leishmania amazonensis.  PLoS Negl Trop Dis. 2015 May 22;9(5):e0003804. Download PDF
  28. Sinclair, JW and Hamza I.  Lessons from bloodless worms: Heme homeostasis in C. elegans.  Biometals. 2015; 28:481-489. Download PDF
  29. Korolnek T and Hamza I.  Macrophages and iron trafficking at the birth and death of red cells.  Blood. 2015;125:2893-2897. Download PDF
  30. Samuel TK, Sinclair JW, Pinter KL, and Hamza I. Culturing Caenorhabditis elegans in Axenic Liquid Media and Creation of Transgenic Worms by Microparticle Bombardment. J Vis Exp. 2014 Aug 2;(90). doi: 10.3791/51796. Download PDF
  31. Korolnek T and Hamza I. Like Iron in the Blood of the People: The Requirement for Heme Trafficking in Iron Metabolism. Front Pharmacol. 2014 Jun 4;5:126. eCollection 2014. Download PDF
  32. Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014;19:1008-1019. Download PDF
  33. Yuan X, Fleming MD and Hamza I. Heme transport and erythropoiesis. Curr Opin Chem Biol. 2013 Apr;17(2):204-211 (Cover Illustration). Download PDF
  34. White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD and Hamza I. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013; 17: 261-270. Download PDF       
    Highlighted by Science Daily, Protein that allows safe recycling of iron from old red blood cells identified.
  35. Hamza I and Dailey H. Porphyrin and Heme Trafficking in Metazoans. In: Handbook of Porphyrin Science with Applications to Chemistry, Physics, Materials Science, Engineering, Biology and Medicine. Edited by Kadish KM, Smith KM, Guilard R, Vol.26: Heme Biochemistry: Guest Editor: Gloria C. Ferreira. World Scientific Publishing Co.; 2013. Download PDF
  36. Fleming MD and Hamza I. Mitochondrial heme: an exit strategy at last. J Clin Invest. 2012; 122:4328-4330. Download PDF
  37. Hamza I and Dailey H. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in eukaryotes. Biochim Biophys Acta. 2012;1823:1617-1632. Download PDF
  38. Huynh C, Yuan X, Miguel DC, Renberg R, Protchenko O, Philpott CC, Hamza I and Andrews NW. Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1. PLoS Pathog 2012; 8: e1002795. Download PDF
  39. Chen C, Samuel TK, Krause M, Dailey HA, and Hamza I. Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by Heme Responsive Gene-2. J Biol Chem. 2012; 287:9601-12. Epub 2012 Feb 2. Download PDF
  40. Yuan X, Protchenko O, Philpott CC, and Hamza I. Topologically conserved residues direct heme transport in HRG-1-related proteins. J Biol Chem. 2012;287:4914-4924. Epub 2011 Dec 15. Download PDF
  41. Chen C, Samuel TK, Sinclair J, Dailey H and Hamza I. An intercellular heme trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell. 2011; 145:720-731. Download PDF;       
    Highlighted by Science Daily, Iron Ferrying Protein May be 'Universal Achillis Heel' for Parasitic Worms.
  42. Severance S, Chen C, Hamza I. Eukaryotic Heme Trafficking. In: Handbook of Porphyrin Science. Edited by Kadish KM, Smith KM, Guilard R, vol. 15: Biochemistry of Tetrapyrroles: World Scientific Publishing Co.; 2011: 1-48. Download PDF
  43. Sinclair J and Hamza I. A novel heme response element mediates transcriptional regulation in Caenorhabditis elegans. J Biol Chem. 2010; 285:39536-39543. Download PDF
  44. Severance S, Rajagopal A, Rao AU, Cerqueira GC, Mitreva M, El-Sayed NM, Krause M and Hamza I. Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genetics 2010;6:e1001044. Download PDF
  45. Schultz I, Chen C, Paw B and Hamza I. Iron and porphyrin trafficking in heme biogenesis. J. Biol. Chem. Jun 2010 (Epub). Download PDF
  46. Ihrig J, Hausmann A, Hain A, Richter N, Hamza I, Lill R and Mühlenhoff U. Iron regulation through the back door: Iron-dependent metabolite levels contribute to the transcriptional adaptation to iron deprivation in S. cerevisiae. Eukaryot Cell. 2010; 9:460-471 Download PDF
  47. Severance S and Hamza I. Trafficking of Heme and Porphyrins in Metazoa. Chem. Rev. 2009; 109:4596-4616. Download PDF
  48. Wu B, Novelli J, Foster J, Vaisvila R, Conway L, Ingram J, Ganatra M, Rao AU, Hamza I, Slatko B. The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target. PLoS Negl Trop Dis. 2009 3:e475. Download PDF
  49. Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I. Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008; 453: 1127-1131 Download PDF       
    Highlighted by United Press International, Worms help in iron deficiency research
  50. Nass R and Hamza I. The Nematode C. elegans as an Animal Model to Explore Toxicology In Vivo: Solid and Axenic Growth Culture Conditions and Compound Exposure Parameters. In: Current Protocols in Toxicology Eds. Bus, JS, Costa LG, Hodgson E, Lawrence DA and Reed DJ. John Wiley & Sons, Inc., 2007; Unit 1.9 1.9.1-1.9.17. Download PDF
  51. Hamza I. Intracellular Trafficking of Porphyrins. ACS Chem. Biol. 2006;1: 627–629 Download PDF
  52. Held MR, Bungiro RD, Harrison LM, Hamza I and Cappello M. Dietary iron content mediates hookworm pathogenesis in vivo. Infect Immun. 2006;74:289-295 Download PDF.       
    Highlighted in Science magazine
  53. Rao A, Carta L, Lesuisse E and Hamza I. Lack of Heme Synthesis in a Free-Living Eukaryote. Proc Natl Acad Sci. 2005; 102:4270-4275 Download PDF (Supporting Data)
  54. Hamza I, Prohaska JR and Gitlin. JD. Essential Role for Atox1 in the Copper-Mediated Intracellular Trafficking of the Menkes ATPase. Proc Natl Acad Sci. 2003; 100:1215-1220 Download PDF.
  55. Hamza I and Gitlin JD. Copper chaperones for cytochrome c oxidase and human disease. J Bioenerg Biomembr. 2002; 34:381-388 Download PDF.
  56. Hamza I and Gitlin JD. Hepatic Copper Transport. In: Molecular Pathogenesis of Cholestasis Ed. Trauner, M and Jansen P. Landes Bioscience, Austin, Texas 2002.
  57. Hamza I and Gitlin JD. Copper-transporting ATPases. In: The Encyclopedia of Molecular Medicine Ed. Creighton T. New York, John Wiley & Sons, 2002; 904-906.
  58. Hamza I, Faisst A, Prohaska JR, Chen J, Gruss P and Gitlin. JD. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci. 2001; 98: 6848-6852 Download PDF       
    Editorial in PNAS by Andrews NC       
    Highlighted in BBC World News
  59. Hamza I and Gitlin JD. Copper metabolism and the Liver. In: The Liver: Biology and Pathobiology. I Arias, Boyer, F Chisari, N Fausto, D Schachter and D Shafritz (eds) Williams and Wilkins, 2001; 331-343.
  60. Hamza I, Klomp LWJ, Gaedigk R, White RA and Gitlin JD. Structure, expression and chromosomal localization of the mouse Atox1 gene. Genomics 2000; 63:294-297 Download PDF.
  61. Hamza I, Qi Z, King ND and O'Brian MR. Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum. Microbiology 2000; 146:669-676 Download PDF.
  62. Hamza I, Schaefer M, Klomp LWJ and Gitlin JD. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc Natl Acad Sci. 1999; 96:13363-13368 Download PDF.
  63. Qi Z, Hamza I and O'Brian MR. Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci. 1999; 96:13056-13061 Download PDF.
  64. Hamza I, Hassett R and O'Brian MR. Identification of a functional fur gene in Bradyrhizobium japonicum. J Bacteriol. 1999; 181:5843-5846 Download PDF.
  65. Hamza I, Chauhan S, Hassett R and O'Brian MR. The bacterial Irr protein is required for coordination of heme biosynthesis with iron availability. J Biol Chem. 1998; 273:21669-21674 Download PDF.